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Circulating endothelial progenitor cells and clinical outcome in patients with congestive heart failure.
- Source :
-
Heart (British Cardiac Society) [Heart] 2007 Sep; Vol. 93 (9), pp. 1046-50. Date of Electronic Publication: 2007 Feb 03. - Publication Year :
- 2007
-
Abstract
- Background: Circulating endothelial progenitor cells (EPCs) are increased in conditions associated with ischaemia and can potentially support angiogenesis and vasculogenesis. EPC levels were also shown to predict outcome in patients with atherosclerotic vascular disease. We tested the hypothesis that circulating EPC can predict outcome in patients with congestive heart failure (CHF).<br />Methods: EPC-colony-forming units were measured in the peripheral blood of 107 consecutive patients with CHF with New York Heart Association (NYHA) functional class II-IV. Serum levels of vascular endothelial growth factor (VEGF), N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) and high-sensitivity C-reactive protein (hsCRP) were also measured. End points were defined as CHF-related hospital admissions and all-cause mortality.<br />Results: Age (p = 0.01), diabetes mellitus (p = 0.002) and EPC levels (p = 0.02) were found to be independent predictors of all-cause mortality. EPC levels did not predict CHF-related hospitalisations. EPC levels correlated positively with NYHA (p = 0.05, r = 0.19), but did not correlate with VEGF, NT-pro-BNP or hsCRP. EPC levels did not differ by the aetiology of CHF.<br />Conclusions: EPC levels are independent predictors of all-cause mortality among patients with CHF.
- Subjects :
- Aged
Aged, 80 and over
Biomarkers blood
C-Reactive Protein analysis
Colony-Forming Units Assay
Endothelium, Vascular pathology
Female
Heart Failure pathology
Hospitalization
Humans
Male
Middle Aged
Natriuretic Peptide, Brain blood
Peptide Fragments blood
Prognosis
Risk Factors
Survival Analysis
Vascular Endothelial Growth Factor A blood
Endothelial Cells physiology
Heart Failure blood
Stem Cells physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1468-201X
- Volume :
- 93
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Heart (British Cardiac Society)
- Publication Type :
- Academic Journal
- Accession number :
- 17277352
- Full Text :
- https://doi.org/10.1136/hrt.2006.102657