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The genetic basis of abdominal aortic aneurysms: a review.
- Source :
-
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery [Eur J Vasc Endovasc Surg] 2007 Apr; Vol. 33 (4), pp. 381-90. Date of Electronic Publication: 2007 Feb 02. - Publication Year :
- 2007
-
Abstract
- Introduction: The pathogenesis of abdominal aortic aneurysm (AAA) remains poorly understood, however significant evidence has emerged in recent years to suggest a chronic inflammatory process. Observational studies have highlighted a familial trend towards AAA development among relatives of affected individuals and it is thought that inflammatory genes may influence an individual's susceptibility. Conflicting reports exist over single gene versus multiple gene inheritance patterns in addition to a collection of studies examining individual inflammatory genes. This paper reviews the evidence for a genetic predisposition to aneurysm formation including familial and segregation studies in addition to experimental evidence investigating specific candidate genes.<br />Method: Medline and Pubmed database searches were conducted using the search terms abdominal aortic aneurysm and gene. Papers were reviewed and references manually searched for further relevant publications which were added to the data. Papers were categorised under the headings familial, segregation and candidate gene studies.<br />Results: A review of 58 papers is presented under sub-headings as above. In the case of the candidate gene section, a brief report of the functional relevance of each gene is included.<br />Conclusion: A summary of the evidence presented is given and the direction of future work in this field is briefly considered.
- Subjects :
- Aortic Aneurysm, Abdominal epidemiology
Family
Genetic Predisposition to Disease
HLA Antigens genetics
Humans
Incidence
Inflammation genetics
Interleukins genetics
Matrix Metalloproteinases, Secreted genetics
Methylenetetrahydrofolate Reductase (NADPH2) genetics
Models, Genetic
Nitric Oxide Synthase genetics
Peptidyl-Dipeptidase A genetics
Plasminogen Activator Inhibitor 1 genetics
Platelet Activating Factor genetics
Receptors, CCR2
Receptors, Chemokine genetics
Tissue Inhibitor of Metalloproteinases genetics
Aortic Aneurysm, Abdominal genetics
Inheritance Patterns
Polymorphism, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 1078-5884
- Volume :
- 33
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 17276705
- Full Text :
- https://doi.org/10.1016/j.ejvs.2006.10.025