Back to Search
Start Over
Quantification of trade-off between parotid gland sparing and planning target volume underdosages in clinically node-negative head-and-neck intensity-modulated radiotherapy.
- Source :
-
International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2007 May 01; Vol. 68 (1), pp. 136-43. Date of Electronic Publication: 2007 Feb 02. - Publication Year :
- 2007
-
Abstract
- Purpose: To quantify the trade-off between parotid gland sparing and planning target volume (PTV) underdosages for head-and-neck intensity-modulated radiotherapy.<br />Methods and Materials: A planning study was performed for 4 patients with either soft palate or tonsil tumors treated with external radiotherapy up to 46 Gy. The trade-off between underdosages in the PTV and sparing of the parotid glands was investigated by systematically varying the optimization objectives for the inverse planning. A new way of presenting dose-volume information allows easy detection of small PTV subvolumes with underdosages that cannot be assessed in conventional cumulative dose-volume histograms. A simple radiobiological model to estimate the control probability for an electively irradiated neck level was developed.<br />Results: The average dose to the parotid glands can decrease by >10 Gy by allowing the PTV to be underdosed in such a way that the radiobiological model predicts a decrease in subclinical disease control probability of (typically) 1% to a few percent.<br />Conclusion: The trade-off between parotid gland sparing and underdosages in the PTV has been quantified by the use of an alternative method to present dose-volume information and by the use of a radiobiological model to predict subclinical disease control probability.
- Subjects :
- Dose-Response Relationship, Radiation
Humans
Palatal Neoplasms diagnostic imaging
Radiobiology
Radiotherapy Dosage
Tomography, X-Ray Computed
Tonsillar Neoplasms diagnostic imaging
Palatal Neoplasms radiotherapy
Palate, Soft diagnostic imaging
Parotid Gland diagnostic imaging
Radiotherapy, Intensity-Modulated
Tonsillar Neoplasms radiotherapy
Subjects
Details
- Language :
- English
- ISSN :
- 0360-3016
- Volume :
- 68
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of radiation oncology, biology, physics
- Publication Type :
- Academic Journal
- Accession number :
- 17276611
- Full Text :
- https://doi.org/10.1016/j.ijrobp.2006.11.049