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Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis.
- Source :
-
Cell metabolism [Cell Metab] 2007 Feb; Vol. 5 (2), pp. 151-6. - Publication Year :
- 2007
-
Abstract
- Recent studies have demonstrated a strong relationship between aging-associated reductions in mitochondrial function, dysregulated intracellular lipid metabolism, and insulin resistance. Given the important role of the AMP-activated protein kinase (AMPK) in the regulation of fat oxidation and mitochondrial biogenesis, we examined AMPK activity in young and old rats and found that acute stimulation of AMPK-alpha(2) activity by 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) and exercise was blunted in skeletal muscle of old rats. Furthermore, mitochondrial biogenesis in response to chronic activation of AMPK with beta-guanidinopropionic acid (beta-GPA) feeding was also diminished in old rats. These results suggest that aging-associated reductions in AMPK activity may be an important contributing factor in the reduced mitochondrial function and dysregulated intracellular lipid metabolism associated with aging.
- Subjects :
- AMP-Activated Protein Kinase Kinases
AMP-Activated Protein Kinases
Aminoimidazole Carboxamide analogs & derivatives
Aminoimidazole Carboxamide pharmacology
Animals
Guanidines administration & dosage
Guanidines pharmacology
Male
Mitochondria drug effects
Physical Conditioning, Animal
Propionates administration & dosage
Propionates pharmacology
Rats
Rats, Inbred F344
Ribonucleotides pharmacology
Aging
Mitochondria enzymology
Multienzyme Complexes metabolism
Protein Serine-Threonine Kinases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1550-4131
- Volume :
- 5
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cell metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 17276357
- Full Text :
- https://doi.org/10.1016/j.cmet.2007.01.008