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Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis.

Authors :
Reznick RM
Zong H
Li J
Morino K
Moore IK
Yu HJ
Liu ZX
Dong J
Mustard KJ
Hawley SA
Befroy D
Pypaert M
Hardie DG
Young LH
Shulman GI
Source :
Cell metabolism [Cell Metab] 2007 Feb; Vol. 5 (2), pp. 151-6.
Publication Year :
2007

Abstract

Recent studies have demonstrated a strong relationship between aging-associated reductions in mitochondrial function, dysregulated intracellular lipid metabolism, and insulin resistance. Given the important role of the AMP-activated protein kinase (AMPK) in the regulation of fat oxidation and mitochondrial biogenesis, we examined AMPK activity in young and old rats and found that acute stimulation of AMPK-alpha(2) activity by 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) and exercise was blunted in skeletal muscle of old rats. Furthermore, mitochondrial biogenesis in response to chronic activation of AMPK with beta-guanidinopropionic acid (beta-GPA) feeding was also diminished in old rats. These results suggest that aging-associated reductions in AMPK activity may be an important contributing factor in the reduced mitochondrial function and dysregulated intracellular lipid metabolism associated with aging.

Details

Language :
English
ISSN :
1550-4131
Volume :
5
Issue :
2
Database :
MEDLINE
Journal :
Cell metabolism
Publication Type :
Academic Journal
Accession number :
17276357
Full Text :
https://doi.org/10.1016/j.cmet.2007.01.008