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[Expression regulation of insulin-like growth factor binding proteins (IGFBP). Tissue-specific expression of IGFBP-1].
- Source :
-
Annales d'endocrinologie [Ann Endocrinol (Paris)] 1991; Vol. 52 (6), pp. 447-50. - Publication Year :
- 1991
-
Abstract
- We have investigated the liver-specific expression of IGFBP-1 gene, an Insulin-like Growth Factor binding protein. Northern blot as well as transient transfection experiments, both carried out in differentiated (H4II, C2Rev7) and dedifferentiated (H5, C2) hépatoma cell lines, yielded clear cut data allowing the involvement of HNF1, a liver-specific trans acting factor, in basal IGFBP-1 liver-specific expression.
- Subjects :
- Animals
Humans
Insulin-Like Growth Factor Binding Proteins
Liver Neoplasms, Experimental genetics
Organ Specificity genetics
Promoter Regions, Genetic genetics
Rats
Transcription, Genetic genetics
Transcriptional Activation genetics
Carrier Proteins genetics
Gene Expression Regulation
Insulin-Like Growth Factor I metabolism
Liver
Subjects
Details
- Language :
- French
- ISSN :
- 0003-4266
- Volume :
- 52
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Annales d'endocrinologie
- Publication Type :
- Academic Journal
- Accession number :
- 1726715