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Synthetic non-peptide mimetics of alpha-helices.
- Source :
-
Chemical Society reviews [Chem Soc Rev] 2007 Feb; Vol. 36 (2), pp. 326-34. Date of Electronic Publication: 2007 Jan 04. - Publication Year :
- 2007
-
Abstract
- Proteins in nature fold into native conformations in which combinations of peripherally projected aliphatic, aromatic and ionic functionalities direct a wide range of properties. Alpha-helices, one of the most common protein secondary structures, serve as important recognition regions on protein surfaces for numerous protein-protein, protein-DNA and protein-RNA interactions. These interactions are characterized by conserved structural features within the alpha-helical domain. Rational design of structural mimetics of these domains with synthetic small molecules has proven an effective means to modulate such protein functions. In this tutorial review we discuss strategies that utilize synthetic small-molecule antagonists to selectively target essential protein-protein interactions involved in certain diseases. We also evaluate some of the protein-protein interactions that have been or are potential targets for alpha-helix mimetics.
Details
- Language :
- English
- ISSN :
- 0306-0012
- Volume :
- 36
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Chemical Society reviews
- Publication Type :
- Academic Journal
- Accession number :
- 17264933
- Full Text :
- https://doi.org/10.1039/b608043j