Back to Search
Start Over
Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon- gamma levels.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2007 Mar 01; Vol. 195 (5), pp. 734-8. Date of Electronic Publication: 2007 Jan 18. - Publication Year :
- 2007
-
Abstract
- Interleukin (IL)-18 generates T helper 1-type immunity and inhibits human immunodeficiency virus type 1 (HIV-1) in primary cells in vitro. Because IL-18 may participate in HIV-1 containment, whole-blood IL-18 levels were measured in 20 healthy control subjects and longitudinally in 28 subjects with early HIV-1 infection. Compared with those in control subjects, IL-18 levels were higher during early HIV-1 infection, and IL-18 levels predicted reduced CXCR4 HIV-1 coreceptor expression and diminished interferon (IFN)- gamma levels. By contrast, a direct association between IL-18 and IFN- gamma levels was observed in blood stimulated with lipopolysaccharide. During early HIV-1 infection, IL-18 may regulate HIV-1 coreceptor expression and have antiretroviral activity.
- Subjects :
- Adult
Anti-HIV Agents therapeutic use
Female
HIV Infections drug therapy
HIV Infections immunology
Humans
Interleukin-18 metabolism
Male
Middle Aged
HIV Infections blood
HIV Infections metabolism
HIV-1 isolation & purification
Interferon-gamma metabolism
Interleukin-18 blood
Receptors, CXCR4 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 195
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 17262717
- Full Text :
- https://doi.org/10.1086/511435