Back to Search
Start Over
[Effect of adjuvant chemotherapy of ginsenoside Rg3 combined with mitomycin C and tegafur in advanced gastric cancer].
- Source :
-
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery [Zhonghua Wei Chang Wai Ke Za Zhi] 2007 Jan; Vol. 10 (1), pp. 64-6. - Publication Year :
- 2007
-
Abstract
- Objective: To evaluate the enhancing effects of ginsenoside Rg3 combined with mitomycin C and tegafur (MF) on postoperative chemotherapy in advanced gastric cancer.<br />Methods: Seventy-one postoperative patients with advanced gastric cancer were randomly divided into two groups, the control group (n=33), which received treatment with only MF (Mitomycin C+Tegafur), and the trial group (n=38), which were treated with ginsenoside Rg3+MF. The serum VEGF levels in the control group and trial group were detected preoperatively and postoperatively, meanwhile, the serum VEGF levels in 30 healthy persons were detected as comparison. The relations between patients survival and serum VEGF levels were analyzed.<br />Results: The levels of serum VEGF in advanced gastric cancer were higher than those in healthy persons [(297.8+/-129.6) pg/ml vs (212.3+/-67.5) pg/ml] (P<0.01), and were correlated with the depth of tumor invasion, lymph node metastasis, tumor size > 4 cm and TNM stage (P<0.05). Fourteen weeks after operation, the levels of serum VEGF in trial group decreased below those of preoperation and approached to normal range, while in the control group, the levels of serum VEGF decreased near those of preoperation only. The median survival of patients in trial group and control group were 40 and 25 months respectively. The survival rate of patients in trial group was significantly higher than that in control group (P=0.047).<br />Conclusion: The combined application of ginsenoside Rg3+MF chemotherapy can decrease the concentration of serum VEGF and improve the survival rate in advanced gastric cancer patients.
- Subjects :
- Adult
Aged
Aged, 80 and over
Angiogenesis Inhibitors therapeutic use
Chemotherapy, Adjuvant
Female
Humans
Male
Middle Aged
Neoplasm Staging
Stomach Neoplasms blood
Stomach Neoplasms pathology
Survival Rate
Vascular Endothelial Growth Factor A blood
Ginsenosides therapeutic use
Mitomycin therapeutic use
Phytotherapy
Stomach Neoplasms drug therapy
Tegafur therapeutic use
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1671-0274
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
- Publication Type :
- Academic Journal
- Accession number :
- 17253178