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[The role of the surface antigens of Pseudomonas pseudomallei in the pathogenesis of melioidosis].
- Source :
-
Zhurnal mikrobiologii, epidemiologii i immunobiologii [Zh Mikrobiol Epidemiol Immunobiol] 1991 Oct (10), pp. 8-12. - Publication Year :
- 1991
-
Abstract
- As established with the use of electron-immunochemical techniques, glycoprotein antigen 6 is the outer membrane component of P. pseudomallei cell wall, while glycoprotein antigen 8 is localized on the cell surface as a capsule-like formation. Antigen 6 plays no perceptible role in the realization of the pathogenic properties of the infective agent, but serves as a reliable sign in the differentiation of P. pseudomallei strains into serovars. Subcultures, defective in the synthesis of antigen 8, have sharply reduced virulence for laboratory animals. As revealed in this study, the pathogenetic action of antigen 8 is linked with its pronounced antiphagocytic function. Thus, antigen 8 is considered to be one of the key pathogenicity factors of P. pseudomallei.
- Subjects :
- Animals
Antigenic Variation immunology
Antigens, Bacterial analysis
Antigens, Bacterial isolation & purification
Antigens, Surface analysis
Antigens, Surface isolation & purification
Antigens, Surface toxicity
Burkholderia pseudomallei immunology
Chromatography, Affinity
Cricetinae
Immunohistochemistry
Melioidosis immunology
Melioidosis microbiology
Mesocricetus
Mice
Microscopy, Immunoelectron
Virulence immunology
Antigens, Bacterial toxicity
Burkholderia pseudomallei pathogenicity
Melioidosis etiology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0372-9311
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Zhurnal mikrobiologii, epidemiologii i immunobiologii
- Publication Type :
- Academic Journal
- Accession number :
- 1724862