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FAK is required for axonal sorting by Schwann cells.
- Source :
-
The Journal of cell biology [J Cell Biol] 2007 Jan 29; Vol. 176 (3), pp. 277-82. Date of Electronic Publication: 2007 Jan 22. - Publication Year :
- 2007
-
Abstract
- Signaling by laminins and axonal neuregulin has been implicated in regulating axon sorting by myelin-forming Schwann cells. However, the signal transduction mechanisms are unknown. Focal adhesion kinase (FAK) has been linked to alpha6beta1 integrin and ErbB receptor signaling, and we show that myelination by Schwann cells lacking FAK is severely impaired. Mutant Schwann cells could interdigitate between axon bundles, indicating that FAK signaling was not required for process extension. However, Schwann cell FAK was required to stimulate cell proliferation, suggesting that amyelination was caused by insufficient Schwann cells. ErbB2 receptor and AKT were robustly phosphorylated in mutant Schwann cells, indicating that neuregulin signaling from axons was unimpaired. These findings demonstrate the vital relationship between axon defasciculation and Schwann cell number and show the importance of FAK in regulating cell proliferation in the developing nervous system.
- Subjects :
- Animals
Axons pathology
Axons ultrastructure
Cell Count
Female
Focal Adhesion Kinase 1 genetics
Gene Expression Regulation, Developmental
Mice
Mice, Knockout
Microscopy, Electron
Myelin Sheath enzymology
Myelin Sheath pathology
Nervous System embryology
Nervous System pathology
Pregnancy
Schwann Cells pathology
Schwann Cells ultrastructure
Signal Transduction physiology
Axons enzymology
Cell Communication physiology
Focal Adhesion Kinase 1 metabolism
Nervous System enzymology
Schwann Cells metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9525
- Volume :
- 176
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of cell biology
- Publication Type :
- Academic Journal
- Accession number :
- 17242067
- Full Text :
- https://doi.org/10.1083/jcb.200609021