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Decreased tumor growth in Walker 256 tumor-bearing rats chronically supplemented with fish oil involves COX-2 and PGE2 reduction associated with apoptosis and increased peroxidation.
- Source :
-
Prostaglandins, leukotrienes, and essential fatty acids [Prostaglandins Leukot Essent Fatty Acids] 2007 Feb; Vol. 76 (2), pp. 113-20. Date of Electronic Publication: 2007 Jan 17. - Publication Year :
- 2007
-
Abstract
- Many studies have shown that addition of fish oil (FO) to the diet reduces tumor growth but the mechanism(s) of action involved is (are) still unknown. In this study, we examine some possible mechanisms in tumor-bearing rats chronically supplemented with FO. Male Wistar rats (21 days old) were fed with regular chow and supplemented with coconut or FO (1g/kg body weight) until they reached 70 days of age. Then, they were inoculated with a suspension of Walker 256 ascitic tumor cells (2 x 10(7)ml) and after 14 days they were killed. Supplementation with FO resulted in significantly lower tumor weight, greater tumor cell apoptosis, lower ex vivo tumor cell proliferation, a higher tumor content of lipid peroxides, lower expression of cyclooxygenase-2 (COX-2) in tumor tissue and a lower plasma concentration of prostaglandin E2 than observed in rats fed regular chow or supplemented with coconut oil. These results suggest that reduction of tumor growth by FO involves an increase in apoptosis and of lipid peroxidation in tumor tissue, with a reduction in tumor cell proliferation ex vivo, COX-2 expression and PGE2 production. Thus, FO may act simultaneously through multiple effects to reduce tumor growth. Whether these effects are connected through a single underlying mechanism remains to be seen.
- Subjects :
- Animals
Carcinoma 256, Walker pathology
Cyclooxygenase 2 metabolism
Dietary Supplements
Fatty Acids, Omega-3 pharmacology
Male
Rats
Rats, Wistar
Apoptosis drug effects
Carcinoma 256, Walker diet therapy
Cyclooxygenase 2 drug effects
Dinoprostone blood
Fish Oils pharmacology
Lipid Peroxidation drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0952-3278
- Volume :
- 76
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Prostaglandins, leukotrienes, and essential fatty acids
- Publication Type :
- Academic Journal
- Accession number :
- 17234396
- Full Text :
- https://doi.org/10.1016/j.plefa.2006.11.008