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Vertical ridge augmentation with guided bone regeneration in association with dental implants: an experimental study in dogs.
- Source :
-
Clinical oral implants research [Clin Oral Implants Res] 2007 Feb; Vol. 18 (1), pp. 86-94. - Publication Year :
- 2007
-
Abstract
- Aim: To evaluate the effect of using guided bone regeneration (GBR) with a titanium-reinforced e-PTFE membrane in alveolar bone defects with titanium implants.<br />Material and Methods: Following extraction of three mandibular premolars and a molar on both sides of the jaw in three dogs, alveolar bone defects (depth: 5-7 mm) were produced. After 4 months, three implants were inserted into each defect to a depth of approximately 4 mm, so that their coronal portion was protruding about 5 mm. Four sides in the dogs were assigned to a test group and the remaining two sides to a control group. The 12 implants in the test group were covered with a reinforced e-PTFE membrane. The space under the membrane was filled with peripheral venous blood from the animal, and the flaps were sutured over the membrane. The six control implants received no membrane before the suturing of the flaps to complete wound closure. The animals were sacrificed after 6 months, and non-decalcified histological specimens of the implants and surrounding tissues were prepared.<br />Results: Histologic and histomorphometric analyses revealed a significantly (Mann-Whitney test; P=0.08) larger amount of bone fill in the test group (mean=57.42%) than in the controls (mean=11.65%), and clinical evaluation of one test site showed that the implants were completely covered with tissue resembling bone. In most of the specimens, bone had grown in height close to, or in direct contact with the membrane. However, the new bone generally was not in direct contact with the implants. Regularly, a zone of dense connective tissue was interposed between the implants and the newly formed bone.<br />Conclusion: The formation of even considerable amounts of bone following vertical ridge augmentation with GBR and implants was not accompanied by predictable osseointegration of the implants.
- Subjects :
- Alveolar Bone Loss pathology
Alveolar Bone Loss surgery
Alveolar Process pathology
Animals
Biocompatible Materials
Connective Tissue pathology
Dental Implantation, Endosseous methods
Dogs
Image Processing, Computer-Assisted
Mandible pathology
Mandible surgery
Membranes, Artificial
Osteogenesis physiology
Polytetrafluoroethylene
Random Allocation
Surgical Flaps
Titanium
Alveolar Ridge Augmentation methods
Bone Regeneration physiology
Dental Implants
Guided Tissue Regeneration, Periodontal methods
Subjects
Details
- Language :
- English
- ISSN :
- 0905-7161
- Volume :
- 18
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical oral implants research
- Publication Type :
- Academic Journal
- Accession number :
- 17224028
- Full Text :
- https://doi.org/10.1111/j.1600-0501.2006.01291.x