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Use of anti-coronavirus antibody testing of cerebrospinal fluid for diagnosis of feline infectious peritonitis involving the central nervous system in cats.
- Source :
-
Journal of the American Veterinary Medical Association [J Am Vet Med Assoc] 2007 Jan 15; Vol. 230 (2), pp. 199-205. - Publication Year :
- 2007
-
Abstract
- Objective: To assess the use of measuring anti-coronavirus IgG in CSF for the diagnosis of feline infectious peritonitis (FIP) involving the CNS in cats.<br />Design: Prospective study.<br />Sample Population: CSF and serum samples from 67 cats.<br />Procedures: CSF and serum samples were allocated into 4 groups: cats with FIP involving the CNS (n = 10), cats with FIP not involving the CNS (13), cats with CNS disorders caused by diseases other than FIP (29), and cats with diseases other than FIP and not involving the CNS (15). Cerebrospinal fluid was evaluated for concentrations of erythrocytes, leukocytes, and total protein. Anti-coronavirus IgG was measured in CSF and serum by indirect immunofluorescence assay.<br />Results: CSF IgG (range of titers, 1:32 to 1:4,096) was detected in 12 cats, including 6 cats with neurologic manifestation of FIP, 4 cats with FIP not involving the CNS, and 2 cats with brain tumors. Cerebrospinal fluid IgG was detected only in cats with correspondingly high serum IgG titers (range, 1:4,096 to 1:16,384) and was positively correlated with serum IgG titers (r = 0.652; P < 0.01), but not with any other CSF parameter. Blood contamination of CSF resulted in < or = 333 erythrocytes/microL in cats with CSF IgG.<br />Conclusions and Clinical Relevance: The correlation between serum and CSF IgG and the fact that CSF IgG was detected only in strongly seropositive cats suggested that CSF anti-coronavirus IgG was derived from blood. Measurement of anti-coronavirus IgG in CSF was of equivocal clinical use.
- Subjects :
- Age Factors
Animals
Cats
Cerebrospinal Fluid virology
Diagnosis, Differential
Female
Immunoglobulin G blood
Immunoglobulin G cerebrospinal fluid
Male
Nervous System Diseases blood
Nervous System Diseases cerebrospinal fluid
Nervous System Diseases diagnosis
Predictive Value of Tests
Prospective Studies
Sensitivity and Specificity
Sex Factors
Antibodies, Viral blood
Antibodies, Viral cerebrospinal fluid
Cerebrospinal Fluid immunology
Coronavirus, Feline immunology
Feline Infectious Peritonitis blood
Feline Infectious Peritonitis cerebrospinal fluid
Feline Infectious Peritonitis diagnosis
Nervous System Diseases veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 0003-1488
- Volume :
- 230
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of the American Veterinary Medical Association
- Publication Type :
- Academic Journal
- Accession number :
- 17223751
- Full Text :
- https://doi.org/10.2460/javma.230.2.199