Biocompatible porous ceramics for the cultivation of hematopoietic cells.

Authors :: Berthold A
Haibel A
Brandes N
Kroh L
Gross U
Uharek L
Schubert H
Source :: Journal of materials science. Materials in medicine [J Mater Sci Mater Med] 2007 Jul; Vol. 18 (7), pp. 1333-8. Date of Electronic Publication: 2007 Jan 13.
Publication Year :: 2007
Abstract: Porous ceramics made of alumina and hydroxyapatite were created using a protein foaming method. Porosity and pore size distribution were successfully varied by means of chemical modification of the foaming protein Bovine serum albumin (BSA). The effectiveness of the BSA and of its chemical modifications as well as the influence of the dispersing agent were investigated using synchrotron tomography. Resulting porous ceramic materials were used as three-dimensional substrates for the cultivation of human peripheral stem cells. The cells proliferated and differentiated in culture. Five cell lines consistent with human blood cell lines were observed.