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Quantification of left ventricular volumes and ejection fraction from gated 99mTc-MIBI SPECT: validation of an elastic surface model approach in comparison to cardiac magnetic resonance imaging, 4D-MSPECT and QGS.
- Source :
-
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2007 Jun; Vol. 34 (6), pp. 900-9. Date of Electronic Publication: 2007 Jan 10. - Publication Year :
- 2007
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Abstract
- Purpose: The segmentation algorithm ESM based on an elastic surface model was validated for the assessment of left ventricular volumes and ejection fraction from ECG-gated myocardial perfusion SPECT. Additionally, it was compared with the commercially available quantification packages 4D-MSPECT and QGS. Cardiac MRI was used as the reference method.<br />Methods: SPECT and MRI were performed on 70 consecutive patients with suspected or proven coronary artery disease. End-diastolic (EDV) and end-systolic (ESV) volumes and left ventricular ejection fraction (LVEF) were derived from SPECT studies by using the segmentation algorithms ESM, 4D-MSPECT and QGS and from cardiac MRI.<br />Results: ESM-derived values for EDV and ESV correlated well with those from cardiac MRI (correlation coefficients R=0.90 and R=0.95, respectively), as did the measurements for LVEF (R=0.86). Both EDV and ESV were slightly overestimated for larger ventricles but not for smaller ventricles; LVEF was slightly overestimated irrespective of ventricle size. The above correlation coefficients are comparable to those for the 4D-MSPECT and QGS segmentation algorithms. However, results obtained with the three segmentation algorithms are not interchangeable.<br />Conclusion: The ESM algorithm can be used to assess EDV, ESV and LVEF from gated perfusion SPECT images. Overall, the performance was similar to that of 4D-MSPECT and QGS when compared with cardiac MRI. Results obtained with the three tested segmentation methods are not interchangeable, so that the same algorithm should be used for follow-up studies and control subjects.
- Subjects :
- Adult
Aged
Aged, 80 and over
Algorithms
Elasticity
Female
Gated Blood-Pool Imaging
Heart Ventricles pathology
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging methods
Male
Middle Aged
Tomography, Emission-Computed, Single-Photon instrumentation
Heart Ventricles diagnostic imaging
Radiopharmaceuticals
Technetium Tc 99m Sestamibi
Tomography, Emission-Computed, Single-Photon methods
Subjects
Details
- Language :
- English
- ISSN :
- 1619-7070
- Volume :
- 34
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- European journal of nuclear medicine and molecular imaging
- Publication Type :
- Academic Journal
- Accession number :
- 17216166
- Full Text :
- https://doi.org/10.1007/s00259-006-0322-0