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Optical and magnetic resonance imaging of cell death and platelet activation using annexin a5-functionalized quantum dots.
- Source :
-
Nano letters [Nano Lett] 2007 Jan; Vol. 7 (1), pp. 93-100. - Publication Year :
- 2007
-
Abstract
- A quantum-dot-based nanoparticle is presented, allowing visualization of cell death and activated platelets with fluorescence imaging and MRI. The particle exhibits intense fluorescence and a large MR relaxivity (r1) of 3000-4500 mM-1 s-1 per nanoparticle due to a newly designed construct increasing the gadolinium-DTPA load. The nanoparticle is suitable for both anatomic and subcellular imaging of structures in the vessel wall and is a promising bimodal contrast agent for future in vivo imaging studies.
Details
- Language :
- English
- ISSN :
- 1530-6984
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nano letters
- Publication Type :
- Academic Journal
- Accession number :
- 17212446
- Full Text :
- https://doi.org/10.1021/nl062226r