Back to Search
Start Over
Intracellular transport of hepatitis B virus.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2007 Jan 07; Vol. 13 (1), pp. 39-47. - Publication Year :
- 2007
-
Abstract
- For genome multiplication hepadnaviruses use the transcriptional machinery of the cell that is found within the nucleus. Thus the viral genome has to be transported through the cytoplasm and nuclear pore. The intracytosolic translocation is facilitated by the viral capsid that surrounds the genome and that interacts with cellular microtubules. The subsequent passage through the nuclear pore complexes (NPC) is mediated by the nuclear transport receptors importin alpha and beta. Importin alpha binds to the C-terminus of the capsid protein that comprises a nuclear localization signal (NLS). The exposure of the NLS is regulated and depends upon genome maturation and/or phosphorylation of the capsid protein. As for other karyophilic cargos using this pathway importin alpha interacts with importin beta that facilitates docking of the import complex to the NPC and the passage through the pore. Being a unique strategy, the import of the viral capsid is incomplete in that it becomes arrested inside the nuclear basket, which is a cage-like structure on the karyoplasmic face of the NPC. Presumably only this compartment provides the factors that are required for capsid disassembly and genome release that is restricted to those capsids comprising a mature viral DNA genome.
- Subjects :
- Active Transport, Cell Nucleus physiology
Biological Transport physiology
Capsid physiology
DNA, Viral metabolism
Hepatocytes metabolism
Hepatocytes pathology
Humans
Microtubules physiology
Nuclear Localization Signals physiology
Nuclear Pore
alpha Karyopherins physiology
beta Karyopherins physiology
Cell Nucleus metabolism
Hepatitis B virus metabolism
Hepatitis B virus pathogenicity
Hepatocytes virology
Subjects
Details
- Language :
- English
- ISSN :
- 1007-9327
- Volume :
- 13
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 17206753
- Full Text :
- https://doi.org/10.3748/wjg.v13.i1.39