Back to Search
Start Over
Abnormalities in CD4+ T lymphocyte subsets in patients with common variable immunodeficiency.
- Source :
-
Clinical immunology and immunopathology [Clin Immunol Immunopathol] 1991 Oct; Vol. 61 (1), pp. 83-92. - Publication Year :
- 1991
-
Abstract
- In order to investigate whether deficient immunoglobulin production in common variable immunodeficiency (CVI) patients was related to defective T cells functions, phenotype and proliferative responses to mitogen of peripheral blood mononuclear cells (PBMC) were investigated in 9 patients with CVI. The results were compared to those of 12 age- and sex-matched normal controls. The numbers of CD3+ and CD8+ T cells in the patients were not different from those in the control group, but the numbers of CD4 T cells were decreased (511 +/- 237 vs 844 +/- 247/mm3; P less than 0.01). The decrease in CD4 T cells was due to a dramatic deficiency in the CD4+ CD45RA+ subset, observed as an absolute value of blood lymphocytes (126 +/- 91 vs 384 +/- 142; P less than 0.001) and as a percentage (9.0 +/- 7.1 vs 18.8 +/- 5.0; P less than 0.01). In contrast, the CD4+ CD29+ T cell subset was not different in CVI from those in the control group. Moreover, there was a strong positive correlation between the number of percentages of CD4+ CD45RA+ blood T cells and the proliferative response of PBMC to PHA (respectively, P less than or equal to 0.02 and P = 0.05) and to Con A (P less than or equal to 0.02). The decrease of CD4+ CD45RA+ T cells could reflect an abnormality in the physiological status of T cells and could be of critical importance in the antibody deficiency.
Details
- Language :
- English
- ISSN :
- 0090-1229
- Volume :
- 61
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical immunology and immunopathology
- Publication Type :
- Academic Journal
- Accession number :
- 1720361
- Full Text :
- https://doi.org/10.1016/s0090-1229(06)80009-7