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Low level nitrate or nitroethane preconditioning enhances the bactericidal effect of suboptimal experimental chlorate treatment against Escherichia coli and Salmonella Typhimurium but not Campylobacter in swine.
- Source :
-
Foodborne pathogens and disease [Foodborne Pathog Dis] 2006 Winter; Vol. 3 (4), pp. 461-5. - Publication Year :
- 2006
-
Abstract
- An experimental chlorate product that targets the respiratory nitrate reductase enzyme of bacteria such as Salmonella and Escherichia coli has shown promising results in reducing concentrations of these bacteria in the gut of food animals. Because expression of the target enzyme is induced by nitrate, we administered short-duration, low level nitrate or nitroethane preconditioning treatments to finishing swine to see if these would enhance the ability of an experimental chlorate product to kill these bacteria. Results from these studies showed that preconditioning the gut microflora of swine with low levels of nitrate or nitrocompounds enhanced (more than tenfold) the ability of the chlorate product to kill Salmonella and E. coli, but not Campylobacter. Further studies are needed before these compounds can be fed as feed additives to animals, although it is likely that nitrate preconditioning may be more near to market than the nitrocompounds, which may require more comprehensive review by regulatory authorities.
- Subjects :
- Animal Feed
Animals
Campylobacter drug effects
Campylobacter enzymology
Campylobacter growth & development
Escherichia coli enzymology
Escherichia coli growth & development
Ethane administration & dosage
Ethane analogs & derivatives
Ethane pharmacology
Food Microbiology
Humans
Nitrates administration & dosage
Nitrates pharmacology
Nitrogen Compounds pharmacology
Nitroparaffins administration & dosage
Nitroparaffins pharmacology
Random Allocation
Salmonella typhimurium enzymology
Salmonella typhimurium growth & development
Swine
Anti-Bacterial Agents pharmacology
Chlorates pharmacology
Escherichia coli drug effects
Nitrate Reductase metabolism
Nitrogen Compounds administration & dosage
Salmonella typhimurium drug effects
Swine Diseases prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1535-3141
- Volume :
- 3
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Foodborne pathogens and disease
- Publication Type :
- Academic Journal
- Accession number :
- 17199529
- Full Text :
- https://doi.org/10.1089/fpd.2006.3.461