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Contribution of oxidative-reductive reactions to high-molecular-weight hyaluronan catabolism.
- Source :
-
Chemistry & biodiversity [Chem Biodivers] 2005 Sep; Vol. 2 (9), pp. 1242-5. - Publication Year :
- 2005
-
Abstract
- Since the content of hyaluronan (HA)-degrading enzymes in synovial fluid (SF), if any, is extremely low, the high rate of HA turnover in SF is to result from a cause different from enzymatic catabolism. An alternative and plausible mechanism is that of oxidative-reductive degradation of HA chains by a combined action of oxygen and transition metal cations maintained in a reduced oxidation state by ascorbate.
Details
- Language :
- English
- ISSN :
- 1612-1880
- Volume :
- 2
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Chemistry & biodiversity
- Publication Type :
- Academic Journal
- Accession number :
- 17193206
- Full Text :
- https://doi.org/10.1002/cbdv.200590094