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Carinatumins A-C, new alkaloids from Lycopodium carinatum inhibiting acetylcholinesterase.
- Source :
-
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2007 Feb 15; Vol. 15 (4), pp. 1703-7. Date of Electronic Publication: 2006 Dec 15. - Publication Year :
- 2007
-
Abstract
- Three new Lycopodium alkaloids, carinatumins A-C (1-3), have been isolated from the club moss Lycopodium carinatum. Structures and stereochemistry of 1-3 were elucidated on the basis of 2D NMR correlations. Carinatumins A (1) and B (2) exhibited a potent inhibitory activity against acetylcholinesterase.
- Subjects :
- Alkaloids chemistry
Alkaloids isolation & purification
Carbenicillin isolation & purification
Carbenicillin pharmacology
Magnetic Resonance Spectroscopy
Molecular Structure
Plants, Medicinal chemistry
Pyridones pharmacology
Stereoisomerism
Carbenicillin analogs & derivatives
Cholinesterase Inhibitors chemistry
Cholinesterase Inhibitors isolation & purification
Lycopodium chemistry
Pyridones isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 0968-0896
- Volume :
- 15
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 17188496
- Full Text :
- https://doi.org/10.1016/j.bmc.2006.12.005