Back to Search
Start Over
Sustained-release erythropoietin ameliorates cardiac function in infarcted rat-heart without inducing polycythemia.
- Source :
-
Circulation journal : official journal of the Japanese Circulation Society [Circ J] 2007 Jan; Vol. 71 (1), pp. 132-7. - Publication Year :
- 2007
-
Abstract
- Background: The usefulness of sustained-release erythropoietin for improving left ventricular (LV) function without polycythemia was evaluated in a rat chronic myocardial infarction model.<br />Methods and Results: Four weeks after left coronary artery ligation, 50 Sprague-Dawley rats were assigned to 5 groups (n=10, each). Control group had a gelatin sheet (20x20 mm) containing saline applied to the infarct area, whereas the 4 treatment groups had gelatin sheets incorporating erythropoietin 0.1 U, 1 U, 10 U and 100 U, respectively. Endpoint measurements performed at 8 weeks after the coronary ligation revealed that the fractional area change was larger for erythropoietin 1 U and 10 U than in the other 3 groups. The LV end-systolic elastance and the time constant of isovolumic relaxation were better for erythropoietin 1 U and 10 U than in the other 3 groups. The density of vessels larger than 50 microm in diameter was the highest in the erythropoietin 1 U group. The number of red blood cells was significantly increased in groups receiving erythropoietin 10 U and 100 U.<br />Conclusions: Gelatin hydrogel sheets incorporating 1 U erythropoietin improved LV function without inducing polycythemia in a rat chronic myocardial infarction model.
- Subjects :
- Animals
Delayed-Action Preparations
Disease Models, Animal
Dose-Response Relationship, Drug
Echocardiography
Erythropoietin administration & dosage
Erythropoietin pharmacology
Gelatin
Heart drug effects
Male
Myocardial Infarction physiopathology
Neovascularization, Physiologic drug effects
Polycythemia physiopathology
Rats
Rats, Sprague-Dawley
Ventricular Dysfunction, Left drug therapy
Ventricular Dysfunction, Left physiopathology
Ventricular Remodeling drug effects
Erythropoietin therapeutic use
Heart physiology
Myocardial Infarction drug therapy
Polycythemia prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1346-9843
- Volume :
- 71
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Circulation journal : official journal of the Japanese Circulation Society
- Publication Type :
- Academic Journal
- Accession number :
- 17186991
- Full Text :
- https://doi.org/10.1253/circj.71.132