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The relationship between cerebral T2 hyperintensity and fixation suppression of vestibulo-ocular reflex in elderly patients with dysequilibrium symptoms.
- Source :
-
Auris, nasus, larynx [Auris Nasus Larynx] 2007 Jun; Vol. 34 (2), pp. 165-71. Date of Electronic Publication: 2006 Dec 19. - Publication Year :
- 2007
-
Abstract
- Objectives: To evaluate the relationship between cerebral T2 hyperintensity on MRI and visual suppression of vestibulo-ocular reflex (VOR) in elderly patients with dysequilibrium symptoms.<br />Methods: Eighty-nine elderly patients with no MRI abnormalities in the infratentorial region aged 60-89 years complaining dysequilibrium symptoms were studied. Cases with whom a definitive diagnosis of peripheral or central disease could be established were not included. T2 hyperintense lesions in the cerebrum: basal ganglia, subcortical white matter and periventricular white matter were evaluated. VOR in darkness and fixation-suppressed VOR using pseudo-sinusoidal rotation stimuli were recorded to calculate visual suppression rate. Correlation between visual suppression rate and semi-quantitative scores for severity of T2 hyperintensity in the cerebrum was investigated.<br />Results: Patients with T2 hyperintensity in the cerebrum exhibited significantly lower visual suppression rate than those without lesions in the cerebrum. Multiple regression analysis showed that visual suppression rate was significantly and negatively correlated with severity of lesions in the basal ganglia, but not with patient age, severity of subcortical white matter lesions, or that of periventricular white matter lesions.<br />Conclusions: In elderly patients with dizziness with a non-specific history and otoneurological findings, fixation suppression of vestibular nystagmus was associated with T2 hyperintensities in the basal ganglia.
- Subjects :
- Aged
Aged, 80 and over
Basal Ganglia physiopathology
Cerebral Cortex pathology
Cerebral Ventricles pathology
Cerebral Ventricles physiopathology
Dizziness pathology
Dominance, Cerebral physiology
Female
Humans
Male
Middle Aged
Nerve Fibers, Myelinated pathology
Nerve Fibers, Myelinated physiology
Statistics as Topic
Vestibular Function Tests
Basal Ganglia pathology
Dizziness physiopathology
Fixation, Ocular physiology
Magnetic Resonance Imaging
Postural Balance physiology
Reflex, Vestibulo-Ocular physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0385-8146
- Volume :
- 34
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Auris, nasus, larynx
- Publication Type :
- Academic Journal
- Accession number :
- 17182204
- Full Text :
- https://doi.org/10.1016/j.anl.2006.09.029