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The effect of monomers on the formulation of polymeric nanocapsules based on polyureas and polyamides.
- Source :
-
International journal of pharmaceutics [Int J Pharm] 2007 Apr 20; Vol. 335 (1-2), pp. 176-179. Date of Electronic Publication: 2006 Nov 10. - Publication Year :
- 2007
-
Abstract
- Formulation of nanocapsules based on polyureas and polyamides have been tested using a patented process. This method based on polycondensation reaction of two complementary monomers and spontaneous formation of oil in water emulsion, is an alternative concept to the known technique based on the same type of reaction used for the formulation of microcapsules, and in which the lipophilic monomer was emulsified in the organic phase before the formation of the polymeric membrane. Nanocapsules can be prepared from different monomers. Wall based on cross-linked polymer contributes to the stability of nanocapsules during and after formulation. The permeability of the polymeric wall is related to its crystallinity and contributes to the growth of nanocapsule membrane by the diffusion of the hydrophilic monomers to get stable colloidal suspensions.
- Subjects :
- Alkanes chemistry
Chemistry, Pharmaceutical
Crystallization
Cyanates chemistry
Diamines chemistry
Drug Compounding
Emulsions
Ethylenediamines chemistry
Isocyanates
Molecular Structure
Oils chemistry
Particle Size
Permeability
Phthalic Acids chemistry
Polyamines chemistry
Toluene 2,4-Diisocyanate chemistry
Water chemistry
Drug Carriers
Nanocapsules
Nylons chemistry
Polymers chemistry
Technology, Pharmaceutical methods
Subjects
Details
- Language :
- English
- ISSN :
- 0378-5173
- Volume :
- 335
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- International journal of pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 17174494
- Full Text :
- https://doi.org/10.1016/j.ijpharm.2006.11.011