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Association between obsessive-compulsive disorder and a variable number of tandem repeats polymorphism in intron 2 of the serotonin transporter gene.
- Source :
-
Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2007 Mar 30; Vol. 31 (2), pp. 416-20. Date of Electronic Publication: 2006 Dec 13. - Publication Year :
- 2007
-
Abstract
- Background: Pharmacological studies indicate a dysregulation of the serotonergic system in obsessive-compulsive disorder (OCD). A variable number tandem repeats (VNTR) polymorphism with three alleles (Stin2.9, Stin2.10, Stin2.12) has been described in intron 2 of the serotonin transporter (5-HTT) gene. This polymorphism has been associated with unipolar depression, bipolar disorder, schizophrenia, and anxiety disorders including OCD.<br />Methods: The association between OCD and the polymorphism is examined in 97 OCD patients, 578 psychiatric controls and 406 healthy controls, all Spanish Caucasians.<br />Results: Genotype frequencies for the polymorphism were significantly different in OCD patients, psychiatric patients and controls. There was a significant excess of 12/12 and 12/10 genotypes in OCD patients compared to psychiatric patients and controls.<br />Conclusions: Our results indicate a possible association between the Stin2.12 allele of the VNTR polymorphism and OCD.
Details
- Language :
- English
- ISSN :
- 0278-5846
- Volume :
- 31
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Progress in neuro-psychopharmacology & biological psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 17174018
- Full Text :
- https://doi.org/10.1016/j.pnpbp.2006.10.016