Back to Search
Start Over
Parathyroid hormone fragment 1-34 inhibits drug-induced inflammation in various experimental models.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 1991 May 30; Vol. 198 (1), pp. 85-8. - Publication Year :
- 1991
-
Abstract
- We investigated the effect of the administration of rat parathyroid hormone-(1-34) on acute or chronic inflammatory processes in different experimental animal models. Fragment 1-34 of parathyroid hormone had an inhibitory effect in all inflammatory acute tests. The dose-response experiments showed that the maximal anti-inflammatory and anti-exudative effects appeared at the dose of 3.30 and 0.33 micrograms/kg, respectively. The anti-inflammatory effect was observed in the first phase of the inflammatory process. In the carrageenin-induced edema test the anti-inflammatory activity began to decline after 180 min. In contrast, this peptide was inactive in the inflammatory chronic test we used.
- Subjects :
- Acetates
Acetic Acid
Animals
Carrageenan
Edema chemically induced
Edema physiopathology
Inflammation chemically induced
Male
Nystatin
Peritonitis chemically induced
Peritonitis physiopathology
Rats
Rats, Inbred Strains
Serotonin
Substance P
Teriparatide
Inflammation drug therapy
Parathyroid Hormone pharmacology
Peptide Fragments pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 198
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 1717293
- Full Text :
- https://doi.org/10.1016/0014-2999(91)90565-8