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Ganglioside-specific IgG and IgA recruit leukocyte effector functions in Guillain-Barré syndrome.
- Source :
-
Journal of neuroimmunology [J Neuroimmunol] 2007 Jan; Vol. 182 (1-2), pp. 177-84. Date of Electronic Publication: 2006 Dec 05. - Publication Year :
- 2007
-
Abstract
- The capacity of ganglioside-specific autoantibodies to recruit leukocyte effector functions was studied. Serum samples from 87 patients with Guillain-Barré (GBS) or Miller Fisher syndrome (MFS), containing GM1-, GQ1b-, or GD1b-specific IgG or IgA, were tested for leukocyte activating capacity. Ganglioside-specific IgG antibodies generally induced leukocyte activation, irrespective of specificity. The magnitude of leukocyte degranulation correlated with GM1- and GQ1b-specific IgG titers, but not with disease severity. Finally, GM1-specific IgA activated leukocytes through the IgA receptor, FcalphaRI (CD89). Therefore, both ganglioside-specific IgG and IgA can recruit leukocyte effector functions, which may be relevant in the pathogenesis of GBS and MFS.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Antibody Specificity
Antigens, CD metabolism
Cell Degranulation
Child
Child, Preschool
Female
G(M1) Ganglioside immunology
Guillain-Barre Syndrome blood
Humans
Leukocytes pathology
Male
Middle Aged
Miller Fisher Syndrome blood
Miller Fisher Syndrome immunology
Receptors, Fc metabolism
Autoantibodies immunology
Gangliosides immunology
Guillain-Barre Syndrome immunology
Immunoglobulin A immunology
Immunoglobulin G immunology
Leukocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0165-5728
- Volume :
- 182
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Journal of neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 17156858
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2006.10.015