Back to Search
Start Over
Effects of interleukin-6 and leukemia inhibitory factor on the acute phase response and DNA synthesis in cultured rat hepatocytes.
- Source :
-
Lymphokine and cytokine research [Lymphokine Cytokine Res] 1991 Apr; Vol. 10 (1-2), pp. 23-6. - Publication Year :
- 1991
-
Abstract
- Human recombinant interleukin-6 (IL-6) and human recombinant leukemia inhibitory factor (LIF) similarly stimulate synthesis of typical acute-phase proteins in the primary rat hepatocyte cultures. LIF is, however, less effective in increasing uptake of alpha-aminoisobutyric acid than IL-6. Antiserum to human IL-6 abolishes induced protein synthesis and amino acid uptake elicited by hrIL-6 but has no effect on the acute-phase response of rat liver cells stimulated by LIF. Both IL-6 and LIF inhibit basal and epidermal growth factor-induced DNA synthesis in rat hepatocytes.
- Subjects :
- Acute-Phase Proteins biosynthesis
Animals
Antigen-Antibody Reactions drug effects
Cells, Cultured
Leukemia Inhibitory Factor
Liver metabolism
Rats
Acute-Phase Reaction chemically induced
DNA biosynthesis
Growth Inhibitors
Interleukin-6 pharmacology
Liver drug effects
Lymphokines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1056-5477
- Volume :
- 10
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Lymphokine and cytokine research
- Publication Type :
- Academic Journal
- Accession number :
- 1714773