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Investigating biological activity spectrum for novel quinoline analogues.
- Source :
-
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2007 Feb 01; Vol. 15 (3), pp. 1280-8. Date of Electronic Publication: 2006 Nov 14. - Publication Year :
- 2007
-
Abstract
- The lack of the wide spectrum of biological data is an important obstacle preventing the efficient molecular design. Quinoline derivatives are known to exhibit a variety of biological effects. In the current publication, we tested a series of novel quinoline analogues for their photosynthesis-inhibiting activity (the inhibition of photosynthetic electron transport in spinach chloroplasts (Spinacia oleracea L.) and the reduction of chlorophyll content in Chlorella vulgaris Beij.). Moreover, antiproliferative activity was measured using SK-N-MC neuroepithelioma cell line. We described the structure-activity relationships (SAR) between the chemical structure and biological effects of the synthesized compounds. We also measured the lipophilicity of the novel compounds by means of the RP-HPLC and illustrate the relationships between the RP-HPLC retention parameter logK (the logarithm of capacity factor K) and logP data calculated by available programs.
- Subjects :
- Antifungal Agents chemical synthesis
Antifungal Agents chemistry
Antineoplastic Agents chemical synthesis
Antineoplastic Agents chemistry
Cell Proliferation drug effects
Chlorophyll
Chromatography, High Pressure Liquid
Electron Transport drug effects
Humans
Microbial Sensitivity Tests
Molecular Structure
Neuroectodermal Tumors, Primitive, Peripheral drug therapy
Photosynthesis drug effects
Quinolines chemical synthesis
Quinolines chemistry
Structure-Activity Relationship
Tumor Cells, Cultured
Antifungal Agents pharmacology
Antineoplastic Agents pharmacology
Chlorella vulgaris drug effects
Chloroplasts drug effects
Quinolines pharmacology
Spinacia oleracea drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0968-0896
- Volume :
- 15
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 17142046
- Full Text :
- https://doi.org/10.1016/j.bmc.2006.11.020