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Progressive multifocal leukoencephalopathy in a haploidentical stem cell transplant recipient: a clinical, neuroradiological and virological response after treatment with risperidone.
- Source :
-
Antiviral research [Antiviral Res] 2007 May; Vol. 74 (2), pp. 156-8. Date of Electronic Publication: 2006 Nov 27. - Publication Year :
- 2007
-
Abstract
- JC virus (JCV) is a double-stranded DNA virus belonging to family Polyomaviridae. It causes progressive multifocal leukoencephalopathy (PML), mainly in immunosuppressed people. JCV had been shown to require the serotonin 2A receptor for host cell entry. We report a case of clinical, neuroradiological and virological response of biopsy-proven PML in a 33-year-old comatose woman after treatment with the anti-psychotic drug risperidone. Since risperidone is the tightest binding of current drugs to this receptor we think this may have blocked JCV entry in our patient, allowing her immune recovery and viral clearance.
- Subjects :
- Adult
Antiviral Agents pharmacology
Female
Humans
Leukoencephalopathy, Progressive Multifocal diagnostic imaging
Leukoencephalopathy, Progressive Multifocal drug therapy
Leukoencephalopathy, Progressive Multifocal physiopathology
Magnetic Resonance Imaging
Precursor Cell Lymphoblastic Leukemia-Lymphoma complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma therapy
Radiography
Risperidone pharmacology
Stem Cell Transplantation
Antiviral Agents therapeutic use
JC Virus drug effects
Leukoencephalopathy, Progressive Multifocal virology
Risperidone therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0166-3542
- Volume :
- 74
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Antiviral research
- Publication Type :
- Academic Journal
- Accession number :
- 17140673
- Full Text :
- https://doi.org/10.1016/j.antiviral.2006.10.011