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[IGF-I, VEGF and bFGF as predictive factors for the onset of retinopathy of prematurity (ROP)].
- Source :
-
Archivos de la Sociedad Espanola de Oftalmologia [Arch Soc Esp Oftalmol] 2006 Nov; Vol. 81 (11), pp. 641-6. - Publication Year :
- 2006
-
Abstract
- Objective: To determine if IGF-I, VEGF and bFGF, present in the serum of premature infants, are independent risk factors of the development of ROP. It was also our objective to design a multivariate model that included these three cytokines as indicator parameters in the ROP screening, in addition to the other parameters already in existence.<br />Methods: 74 patients were recruited with a birth weight below 1500g or gestational age below 32 weeks. These were classified into those who developed ROP (N = 37) and those without ROP (N = 37). We obtained serum from each infant at the time of the first examination at 4-6 postnatal weeks. These samples were frozen until the time of analysis. The roles of gestational age and birth weight were also evaluated.<br />Results: There were significant differences in the amount of the cytokines IGF-I and VEGF between the groups with or without ROP, but there were no significant differences for bFGF. The differences enabled us to establish a multivariate model including IGF-I and VEGF for the prediction of risk of ROP.<br />Conclusions: Cytokine serum levels in premature infants can be useful as an indicator in ROP screening, as well as being used to predict the probability of suffering the illness.
Details
- Language :
- Spanish; Castilian
- ISSN :
- 0365-6691
- Volume :
- 81
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Archivos de la Sociedad Espanola de Oftalmologia
- Publication Type :
- Academic Journal
- Accession number :
- 17136637
- Full Text :
- https://doi.org/10.4321/s0365-66912006001100005