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Evidence of c-myc gene abnormalities in mediastinal large B-cell lymphoma of young adult age.
- Source :
-
Blood [Blood] 1991 Aug 01; Vol. 78 (3), pp. 780-8. - Publication Year :
- 1991
-
Abstract
- Six cases of mediastinal large B-cell lymphoma (MLCL) with sclerosis were analyzed for the presence and patterns of c-myc and bcl-2 loci rearrangements, and for the presence of Epstein-Barr virus DNA sequences by Southern blot hybridization, c-myc gene alterations were found in three of six cases. Two cases showed the presence of mutations or small rearrangements at the 3' end of the first exon. The c-myc gene abnormalities found in these two cases are similar to those observed in the translocation 8;14 of the endemic Burkitt's lymphomas or in its variants t(2;8) and t(8;22). A third case showed a major rearrangement of c-myc gene, with truncation within its first intron, similar to those observed in sporadic Burkitt's and in acquired immunodeficiency-associated lymphomas. None of the cases displayed bcl-2 gene rearrangements or contained viral sequences. Our data suggest a possible role for a translocation-mediated c-myc activation in the pathogenesis of MLCL. Conversely, bcl-2 gene and Epstein-Barr virus do not appear to be involved in the pathogenesis of these peculiar lymphomas. The association between c-myc structural modifications and MLCL also seems to be of relevance in light of the peculiar tendency of this tumor to involve unusual extranodal site (eg, kidney), reminiscent of the spreading attitude of Burkitt's limphomas.
- Subjects :
- Adult
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Bleomycin administration & dosage
Combined Modality Therapy
Cyclophosphamide administration & dosage
DNA Probes
DNA, Neoplasm genetics
DNA, Neoplasm isolation & purification
Doxorubicin administration & dosage
Female
Gene Rearrangement
Humans
Leucovorin administration & dosage
Lymphoma, B-Cell drug therapy
Lymphoma, B-Cell therapy
Male
Mediastinal Neoplasms drug therapy
Mediastinal Neoplasms therapy
Methotrexate administration & dosage
Nucleic Acid Hybridization
Prednisone administration & dosage
Restriction Mapping
Vincristine administration & dosage
Chromosome Aberrations
Chromosome Disorders
Genes, myc
Lymphoma, B-Cell genetics
Mediastinal Neoplasms genetics
Proto-Oncogenes
Subjects
Details
- Language :
- English
- ISSN :
- 0006-4971
- Volume :
- 78
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Blood
- Publication Type :
- Academic Journal
- Accession number :
- 1713514