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Respiratory viral infections and early asthma in childhood.

Authors :
Oh JW
Source :
Allergology international : official journal of the Japanese Society of Allergology [Allergol Int] 2006 Dec; Vol. 55 (4), pp. 369-72.
Publication Year :
2006

Abstract

Respiratory viral infections profoundly influence the disease activity of wheezing illnesses and asthma in early childhood. Viral bronchiolitis shares many features with asthma and a subset of children develop recurrent wheezing after their initial illness. Recently mechanisms for virus-induced exacerbations of childhood asthma are beginning to be focused on and defined. Viruses cause systemic immune activation and also produce local inflammation. These factors are likely to affect airway pathogenesis leading to airway narrowing, an increase in mucus production, and eventually bronchospasm, and airway obstruction. These new insights related to the pathogenesis and disease activity are likely to provide new targets for the therapy and prevention of early asthma in childhood.

Details

Language :
English
ISSN :
1323-8930
Volume :
55
Issue :
4
Database :
MEDLINE
Journal :
Allergology international : official journal of the Japanese Society of Allergology
Publication Type :
Academic Journal
Accession number :
17130678
Full Text :
https://doi.org/10.2332/allergolint.55.369