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Respiratory viral infections and early asthma in childhood.
- Source :
-
Allergology international : official journal of the Japanese Society of Allergology [Allergol Int] 2006 Dec; Vol. 55 (4), pp. 369-72. - Publication Year :
- 2006
-
Abstract
- Respiratory viral infections profoundly influence the disease activity of wheezing illnesses and asthma in early childhood. Viral bronchiolitis shares many features with asthma and a subset of children develop recurrent wheezing after their initial illness. Recently mechanisms for virus-induced exacerbations of childhood asthma are beginning to be focused on and defined. Viruses cause systemic immune activation and also produce local inflammation. These factors are likely to affect airway pathogenesis leading to airway narrowing, an increase in mucus production, and eventually bronchospasm, and airway obstruction. These new insights related to the pathogenesis and disease activity are likely to provide new targets for the therapy and prevention of early asthma in childhood.
- Subjects :
- Adolescent
Airway Obstruction etiology
Airway Obstruction immunology
Airway Obstruction physiopathology
Asthma genetics
Asthma immunology
Asthma physiopathology
Bronchial Spasm etiology
Bronchial Spasm immunology
Bronchial Spasm physiopathology
Child
Child, Preschool
Genetic Predisposition to Disease
Humans
Infant
Inflammation
Lung physiopathology
Phenotype
Recurrence
Respiratory Sounds
Respiratory Tract Infections genetics
Respiratory Tract Infections immunology
Respiratory Tract Infections physiopathology
Risk Factors
Virus Diseases genetics
Virus Diseases immunology
Virus Diseases physiopathology
Asthma etiology
Respiratory Tract Infections complications
Virus Diseases complications
Subjects
Details
- Language :
- English
- ISSN :
- 1323-8930
- Volume :
- 55
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Allergology international : official journal of the Japanese Society of Allergology
- Publication Type :
- Academic Journal
- Accession number :
- 17130678
- Full Text :
- https://doi.org/10.2332/allergolint.55.369