Back to Search
Start Over
Coexpression of fragile histidine triad and c-kit is relevant for prediction of survival in patients with small cell lung cancer.
- Source :
-
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2006 Nov; Vol. 15 (11), pp. 2232-8. - Publication Year :
- 2006
-
Abstract
- Background: In a retrospective analysis of 195 patients with small cell lung cancer (SCLC), we examined the prognostic value of a coexpression of fragile histidine triad (FHIT) protein and c-kit on patient's survival.<br />Methods: As assessed by immunohistochemistry using formalin-fixed, paraffin-embedded tissue sections, tumors of 195 patients with SCLC were evaluated for FHIT and c-kit coexpression.<br />Results: Coexpression of FHIT and c-kit was observed in 53.3%; a positive expression of either FHIT or c-kit was found in 40.5%. Complete lack of FHIT and c-kit (6.2%) was associated with a significantly shorter survival time for the patients with a mean of 122 +/- 45 days compared with 468 +/- 89 days for patients with lung cancer coexpressing FHIT and c-kit (P = 0.0011). The proportion of FHIT- and c-kit-positive cells within a tumor was also related to survival time. Patients with tumors with a proportion between 0% to 25% of FHIT- and c-kit-positive cells had the worst survival of 157 +/- 34 days compared with 496 +/- 95 days for patients showing >25% FHIT- and c-kit-positive cells (P = 0.0002). Further, variables associated with shorter survival times were low performance status, elevated lactate dehydrogenase level, and advanced tumor stage according to tumor-node-metastasis classification. Multivariate analysis using Cox regression model, including 11 variables, confirmed the prognostic significance of a combined expression of FHIT and c-kit next to tumor stage, performance status, and lactate dehydrogenase level.<br />Conclusions: Differential FHIT and c-kit expression was of prognostic relevance for survival in patients with SCLC and therefore provide useful variables for therapeutic decisions.
- Subjects :
- Acid Anhydride Hydrolases biosynthesis
Adult
Aged
Aged, 80 and over
Female
Humans
L-Lactate Dehydrogenase metabolism
Male
Middle Aged
Neoplasm Proteins biosynthesis
Proportional Hazards Models
Proto-Oncogene Proteins c-kit biosynthesis
Retrospective Studies
Treatment Outcome
Acid Anhydride Hydrolases genetics
Carcinoma, Small Cell genetics
Carcinoma, Small Cell mortality
Lung Neoplasms genetics
Lung Neoplasms mortality
Neoplasm Proteins genetics
Proto-Oncogene Proteins c-kit genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1055-9965
- Volume :
- 15
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 17119051
- Full Text :
- https://doi.org/10.1158/1055-9965.EPI-06-0342