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Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy.
- Source :
-
International journal of radiation biology [Int J Radiat Biol] 2006 Oct; Vol. 82 (10), pp. 699-757. - Publication Year :
- 2006
-
Abstract
- Purpose: The Cancer Imaging Program of the National Cancer Institute convened a workshop to assess the current status of hypoxia imaging, to assess what is known about the biology of hypoxia as it relates to cancer and cancer therapy, and to define clinical scenarios in which in vivo hypoxia imaging could prove valuable.<br />Results: Hypoxia, or low oxygenation, has emerged as an important factor in tumor biology and response to cancer treatment. It has been correlated with angiogenesis, tumor aggressiveness, local recurrence, and metastasis, and it appears to be a prognostic factor for several cancers, including those of the cervix, head and neck, prostate, pancreas, and brain. The relationship between tumor oxygenation and response to radiation therapy has been well established, but hypoxia also affects and is affected by some chemotherapeutic agents. Although hypoxia is an important aspect of tumor physiology and response to treatment, the lack of simple and efficient methods to measure and image oxygenation hampers further understanding and limits their prognostic usefulness. There is no gold standard for measuring hypoxia; Eppendorf measurement of pO(2) has been used, but this method is invasive. Recent studies have focused on molecular markers of hypoxia, such as hypoxia inducible factor 1 (HIF-1) and carbonic anhydrase isozyme IX (CA-IX), and on developing noninvasive imaging techniques.<br />Conclusions: This workshop yielded recommendations on using hypoxia measurement to identify patients who would respond best to radiation therapy, which would improve treatment planning. This represents a narrow focus, as hypoxia measurement might also prove useful in drug development and in increasing our understanding of tumor biology.
- Subjects :
- Antigens, Neoplasm metabolism
Antineoplastic Combined Chemotherapy Protocols adverse effects
Biomarkers, Tumor analysis
Carbonic Anhydrase IX
Carbonic Anhydrases metabolism
Humans
Hypoxia-Inducible Factor 1 metabolism
Isoenzymes metabolism
National Institutes of Health (U.S.)
Neoplasms diagnostic imaging
Neoplasms pathology
Prognosis
Radiography
Reproducibility of Results
United States
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Diagnostic Imaging methods
Hypoxia diagnosis
Neoplasms drug therapy
Oxygen metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0955-3002
- Volume :
- 82
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- International journal of radiation biology
- Publication Type :
- Academic Journal
- Accession number :
- 17118889
- Full Text :
- https://doi.org/10.1080/09553000601002324