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First characterization of fluoroquinolone resistance in Streptococcus suis.

Authors :
Escudero JA
San Millan A
Catalan A
de la Campa AG
Rivero E
Lopez G
Dominguez L
Moreno MA
Gonzalez-Zorn B
Source :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2007 Feb; Vol. 51 (2), pp. 777-82. Date of Electronic Publication: 2006 Nov 20.
Publication Year :
2007

Abstract

We have identified and sequenced the genes encoding the quinolone-resistance determining region (QRDR) of ParC and GyrA in fluoroquinolone-susceptible and -resistant Streptococcus suis clinical isolates. Resistance is the consequence of single point mutations in the QRDRs of ParC and GyrA and is not due to clonal spread of resistant strains or horizontal gene transfer with other bacteria.

Subjects

Subjects :
Amino Acid Sequence
DNA Gyrase genetics
DNA Topoisomerase IV genetics
Female
Genes, Bacterial
Humans
Male
Molecular Sequence Data
Point Mutation
RNA, Ribosomal, 16S genetics
Sequence Alignment
Drug Resistance, Bacterial genetics
Fluoroquinolones pharmacology
Streptococcus suis drug effects
Streptococcus suis genetics

Details

Language :
English
ISSN :
0066-4804
Volume :
51
Issue :
2
Database :
MEDLINE
Journal :
Antimicrobial agents and chemotherapy
Publication Type :
Academic Journal
Accession number :
17116660
Full Text :
https://doi.org/10.1128/AAC.00972-06
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