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In vivo effect of bradykinin during ischemia and reperfusion: improved electrical stability two weeks after myocardial infarction in the pig.
- Source :
-
Journal of cardiovascular pharmacology [J Cardiovasc Pharmacol] 1991 Apr; Vol. 17 (4), pp. 600-7. - Publication Year :
- 1991
-
Abstract
- In this study, the effect of bradykinin or saline infusion during ischemia and reperfusion on electrical stability, 2 weeks after myocardial infarction, was assessed. Acute myocardial infarction was induced in 21 pigs by a transluminal occlusion of the left coronary artery with a catheter balloon, inflated for 45 min. Bradykinin was administered by a 30-min infusion that started after 30 min of coronary occlusion and was continued until 15 min after reperfusion. Although creatine kinase levels in bradykinin-treated animals were significantly lower (p less than 0.001), 2 week survival was not different between groups. In survivors, the filtered QRS (ventricular deflection) duration (detected using signal-averaged electrocardiography) was significantly prolonged in saline-treated pigs, whereas in bradykinin-treated pigs this prolongation was prevented. The terminal voltage of the QRS complex was significantly lower in saline-treated pigs than in bradykinin-treated pigs. These two parameters signify an improved electrical stability after bradykinin treatment. Refractory periods in saline-treated hearts were longer than in bradykinin-treated hearts (106 +/- 10% vs. 95 +/- 13%, p less than 0.05). Also, current thresholds in the infarct border zones showed a greater variance in saline-treated hearts (p less than 0.001), pointing toward more tissue heterogeneity of the infarct border zone. Programmed electrical stimulation showed a trend toward reduced inducibility of sustained ventricular tachycardia in bradykinin-treated hearts. Therefore, bradykinin improves electrical stability weeks after experimental myocardial infarction.
- Subjects :
- Animals
Arrhythmias, Cardiac chemically induced
Arrhythmias, Cardiac physiopathology
Creatine Kinase metabolism
Electrocardiography
Electrophysiology
Hemodynamics drug effects
Male
Refractory Period, Electrophysiological drug effects
Swine
Bradykinin pharmacology
Coronary Disease physiopathology
Myocardial Infarction physiopathology
Myocardial Reperfusion Injury physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0160-2446
- Volume :
- 17
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of cardiovascular pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 1711627
- Full Text :
- https://doi.org/10.1097/00005344-199104000-00012