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Schizotypy, attention deficit hyperactivity disorder, and dopamine genes.
- Source :
-
Psychiatry and clinical neurosciences [Psychiatry Clin Neurosci] 2006 Dec; Vol. 60 (6), pp. 764-7. - Publication Year :
- 2006
-
Abstract
- Previous research has suggested that there may be overlap between schizophrenia and attention-deficit hyperactivity disorder (ADHD). The relationship between schizotypal personality traits, ADHD features and polymorphisms was evaluated in dopamine-related genes. Thirty-one healthy, Caucasian men completed the Rust Inventory of Schizotypal Cognitions (RISC) and the ADHD Self-Report Scale (ASRS). Catechol-O-methyltransferase (COMT) Val158Met, dopamine receptors of the D3 type (DRD3) Ser9Gly, DRD4 variable number of tandem repeats (VNTR), and SLC6A3 VNTR polymorphisms were analyzed. RISC score was correlated with ASRS score (r = 0.54, P = 0.003). COMT Met homozygotes had higher ASRS scores than Val homozygotes (P = 0.005). These findings are consistent with evidence of overlap between schizophrenia and ADHD and support an involvement of COMT genotype in ADHD features.
- Subjects :
- Adult
Alleles
Catechol O-Methyltransferase genetics
Cognition physiology
DNA genetics
Dopamine Plasma Membrane Transport Proteins genetics
Gene Frequency
Genotype
Humans
Male
Polymorphism, Genetic
Psychiatric Status Rating Scales
Receptors, Dopamine D3 genetics
Receptors, Dopamine D4 genetics
Surveys and Questionnaires
Attention Deficit Disorder with Hyperactivity genetics
Dopamine genetics
Schizotypal Personality Disorder genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1323-1316
- Volume :
- 60
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Psychiatry and clinical neurosciences
- Publication Type :
- Academic Journal
- Accession number :
- 17109713
- Full Text :
- https://doi.org/10.1111/j.1440-1819.2006.01594.x