Evidence that FK506 and rapamycin block T cell activation at different sites relative to early reversible phosphorylation involving the protein phosphatases PP1 and PP2A.

Authors :: Metcalfe S
Milner J
Source :: Transplantation [Transplantation] 1991 Jun; Vol. 51 (6), pp. 1318-20.
Publication Year :: 1991

Subjects :: Animals
Cell Cycle drug effects
Cells, Cultured
DNA biosynthesis
Ethers, Cyclic pharmacology
In Vitro Techniques
Mice
Okadaic Acid
Phosphoprotein Phosphatases antagonists & inhibitors
Phosphorylation
Sirolimus
Tacrolimus
Time Factors
Anti-Bacterial Agents pharmacology
Immunosuppressive Agents pharmacology
Lymphocyte Activation drug effects
Phosphoprotein Phosphatases metabolism
Polyenes pharmacology
T-Lymphocytes drug effects

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