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Relation of stavudine discontinuation to anthropometric changes among HIV-infected women.
- Source :
-
Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2007 Jan 01; Vol. 44 (1), pp. 43-8. - Publication Year :
- 2007
-
Abstract
- Objective: To characterize changes in regional anthropometry associated with stavudine exposure and discontinuation.<br />Design: Seven hundred thirty-four HIV-infected participants who reported using stavudine (574 of whom later discontinued stavudine) and 698 HIV-uninfected participants from the Women's Interagency HIV Study provided anthropometrics at 8706 semiannual visits between July 1999 and March 2005.<br />Methods: Changes in weight, waist, chest, upper arm, hip, and midthigh circumferences were evaluated using linear regression with generalized estimating equations.<br />Results: HIV-uninfected women demonstrated increases in regional anthropometry at every body site, whereas HIV-infected women demonstrated decreases in weight and circumferences of the waist, chest, hip, and thigh. A smaller annual decrease in hip circumference was seen after discontinuing stavudine for >2.25 years compared with the decrease observed while on stavudine (P = 0.01). Discontinuing stavudine for >2.25 years was associated with smaller (P < 0.05) decreases in hip (-0.06 cm/y) and thigh (-0.005 cm/y) circumference compared with the decreases observed between 1 and 2.25 years (hip: -0.46 cm/y, thigh: -0.24 cm/y) or < or =1 year (hip: -0.64 cm/y, thigh: -0.27 cm/y) after stavudine discontinuation.<br />Conclusions: Regardless of continuing or discontinuing stavudine, HIV-infected women demonstrate decreases in weight and body circumference measurements over time. The lower limb seems to be most affected by stavudine exposure, with stabilization observed more than 2 years after discontinuation.
- Subjects :
- Adult
Anti-HIV Agents adverse effects
Cohort Studies
Female
HIV Infections etiology
HIV Infections metabolism
HIV-Associated Lipodystrophy Syndrome blood
HIV-Associated Lipodystrophy Syndrome chemically induced
HIV-Associated Lipodystrophy Syndrome pathology
Hip anatomy & histology
Humans
Stavudine adverse effects
Anthropometry
Anti-HIV Agents administration & dosage
HIV Infections drug therapy
Stavudine administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1525-4135
- Volume :
- 44
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of acquired immune deficiency syndromes (1999)
- Publication Type :
- Academic Journal
- Accession number :
- 17091021
- Full Text :
- https://doi.org/10.1097/01.qai.0000248353.56125.43