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[Comparison of efficacy of gabapentin and amitriptyline in the management of peripheral neuropathic pain].
- Source :
-
Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology [Agri] 2006 Apr; Vol. 18 (2), pp. 34-40. - Publication Year :
- 2006
-
Abstract
- In this single center, double blind and randomized trial gabapentin as a new anticonvulsant was compared in efficacy and safety with amitriptyline which is a classic agent in neuropathic pain treatment. Fourty six patients with neuropathic pain which was burning, stabbing and shooting in quality were allocated to take gabapentin (group GBP) and amitriptyline (group AMI) monotherapy. The assesment variables were burning, stabbing, shooting pain on visual analog scale (VAS; 0: no pain, 10: worst pain imaginable), allodynia as present or not by lightly touching the skin with cotton. Primary efficacy variable was the degree of burning, stabbing and shooting pain improvement that was accepted as the difference of beginning and 4th week's VAS of all pain qualities. The secondary efficacy variable was the patient satisfaction scale determined as whether possible side effects of study drugs affect the patients' daily life. The degree of pain improvement was only seen in shooting pain and was statistically significantly high in group GBP. The patient satisfaction scale was also high in group GBP. Both gabapentin and amitriptyline provided effective pain control in peripheral neuropathic pain. Additionally gabapentin was more effective especially in paroxysmal shooting pain than other pain qualities. And also gabapentin was tolerated well.
- Subjects :
- Amines administration & dosage
Amitriptyline administration & dosage
Anticonvulsants administration & dosage
Cyclohexanecarboxylic Acids administration & dosage
Double-Blind Method
Female
Gabapentin
Humans
Male
Middle Aged
Neuralgia pathology
Pain Measurement
Patient Satisfaction
Treatment Outcome
gamma-Aminobutyric Acid administration & dosage
Amines therapeutic use
Amitriptyline therapeutic use
Anticonvulsants therapeutic use
Cyclohexanecarboxylic Acids therapeutic use
Neuralgia drug therapy
gamma-Aminobutyric Acid therapeutic use
Subjects
Details
- Language :
- Turkish
- ISSN :
- 1300-0012
- Volume :
- 18
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology
- Publication Type :
- Academic Journal
- Accession number :
- 17089234