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Role of gp91phox-containing NADPH oxidase in the deoxycorticosterone acetate-salt-induced hypertension.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 2006 Dec 15; Vol. 552 (1-3), pp. 131-4. Date of Electronic Publication: 2006 Sep 28. - Publication Year :
- 2006
-
Abstract
- NADPH oxidase plays an important role in vascular oxidative stress in hypertensive diseases. We evaluated whether NADPH oxidase-dependent superoxide (O(2)(-)) production is involved in the deoxycorticosterone acetate (DOCA)-salt-induced hypertension, using mice which are genetically deficient in gp91phox, an NADPH oxidase subunit protein (gp91(-/-) mice). Two weeks after the DOCA-salt treatment, systolic blood pressure was significantly elevated in wild-type mice, but not in gp91(-/-) mice. After a 5-week treatment period, wild-type mice developed high blood pressure, with a systolic blood pressure of 127 +/- 3 mm Hg, compared with 107 +/- 4 mm Hg in gp91(-/-) mice. Aortic O(2)(-) production in wild-type DOCA-salt-treated mice was significantly higher than that in wild-type sham mice, whereas there were no significant differences in aortic O(2)(-) production between gp91(-/-) DOCA-salt-treated and sham mice. These findings suggest that vascular O(2)(-) overproduction via gp91phox-containing NADPH oxidase is one of the crucial factors in the development of DOCA-salt-induced hypertension.
- Subjects :
- Animals
Aorta drug effects
Aorta metabolism
Blood Pressure drug effects
Desoxycorticosterone administration & dosage
Genotype
Hypertension chemically induced
Hypertension genetics
Male
Membrane Glycoproteins deficiency
Membrane Glycoproteins physiology
Mice
Mice, Inbred C57BL
Mice, Knockout
NADPH Oxidase 2
NADPH Oxidases deficiency
NADPH Oxidases physiology
Superoxides metabolism
Time Factors
Desoxycorticosterone toxicity
Hypertension physiopathology
Membrane Glycoproteins genetics
NADPH Oxidases genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 552
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 17064681
- Full Text :
- https://doi.org/10.1016/j.ejphar.2006.09.039