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Unique tandem Heck-lactamization naphthyridinone ring formation between acrylanilides and halogenated pyridines.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2006 Oct 27; Vol. 71 (22), pp. 8610-3. - Publication Year :
- 2006
-
Abstract
- The Heck coupling of acrylanilides with 4-bromo-2-chloro-3-iodo-pyridine using palladium acetate can produce bis-Heck products or undergo an unusual tandem Heck-lactamization ring formation to generate 5-chloro-1-aryl-1,6-naphthyridin-2(1H)-ones.
Details
- Language :
- English
- ISSN :
- 0022-3263
- Volume :
- 71
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 17064040
- Full Text :
- https://doi.org/10.1021/jo0613479