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Toll-like receptor-dependent discrimination of streptococci.
- Source :
-
Journal of endotoxin research [J Endotoxin Res] 2006; Vol. 12 (5), pp. 307-12. - Publication Year :
- 2006
-
Abstract
- Streptococcus pneumoniae and Streptococcus agalactiae cause distinct infectious diseases in small children. Similarly, these bacteria elicit very different host-cell responses in vitro. Inactivated S. agalactiae by far exceeds S. pneumoniae in the activation of inflammatory cytokines and upstream signaling intermediates such as the MAP kinase JNK. The inflammatory response to both Streptococcus spp. is mediated by MyD88, an essential adapter protein of Toll-like receptors (TLRs), although the specific TLRs that are involved have not been fully resolved. Furthermore, during logarithmic growth, S. pneumoniae releases pneumolysin that interacts with TLR4 whereas S. agalactiae releases diacylated molecules that interact with TLR2/6. Interaction of these soluble bacterial products with their cognate TLRs is critical for limiting bacterial dissemination and and systemic inflammation in mice. This might be due, in part, to TLR-mediated apoptosis induced by these factors. In conclusion related streptococcal species induce specific events in TLR-mediated signal transduction. Comparative analysis of the host-cell response to these bacteria reveals molecules such as JNK as valuable targets for adjunctive sepsis therapy.
- Subjects :
- Animals
Animals, Newborn
Apoptosis immunology
Apoptosis physiology
Bacterial Proteins metabolism
Humans
Infant, Newborn
JNK Mitogen-Activated Protein Kinases physiology
Ligands
Lipopolysaccharides immunology
Mice
Myeloid Differentiation Factor 88 immunology
Myeloid Differentiation Factor 88 metabolism
Signal Transduction
Streptococcus agalactiae growth & development
Streptococcus agalactiae metabolism
Streptococcus pneumoniae growth & development
Streptococcus pneumoniae metabolism
Streptolysins metabolism
Teichoic Acids immunology
Immunity, Innate
Streptococcus agalactiae immunology
Streptococcus pneumoniae immunology
Toll-Like Receptors immunology
Toll-Like Receptors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0968-0519
- Volume :
- 12
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of endotoxin research
- Publication Type :
- Academic Journal
- Accession number :
- 17059694
- Full Text :
- https://doi.org/10.1179/096805106X118762