Back to Search
Start Over
Metalloantibiotics: synthesis, characterization and in-vitro antibacterial studies on cobalt (II), copper (II), nickel (II) and zinc (II) complexes with cloxacillin.
- Source :
-
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2006 Aug; Vol. 21 (4), pp. 441-8. - Publication Year :
- 2006
-
Abstract
- The synthesis and characterization of cloxacillin (clox) complexes with divalent metal ions [Co (II), Cu (II), Ni (II) and Zn (II)] is described. The nature of bonding of the chelated cloxacillin and the structures of the metal complexes have been elucidated on the basis of their physical and spectroscopic data. In all the complexes, the cloxacillin acts as a uninegatively charged bidentate ligand with coordination involving the carboxylate-O and endocyclic-N of the beta-lactam ring. The new compounds have been screened for in-vitro antibacterial activity against Escherichia coli (a), Klebsiella pneumonae (b), Proteus mirabilis (c), Pseudomonas aeruginosa (d), Salmonella typhi (e), Shigella dysentriae (f), Bacillus cereus (g), Corynebacterium diphtheriae (h), Staphylococcus aureus (j) and Streptococcus pyogenes (k) bacterial strains. The brine shrimp bioassay was also carried out to study their in-vitro cytotoxic properties. All compounds, respectively, showed a promising activity (90%) against five bacterial species at 10 microg/ml concentration and a significant activity (52%) against the same test bacteria at 25 microg/ml concentration.
- Subjects :
- Animals
Anti-Bacterial Agents chemistry
Anti-Infective Agents chemistry
Cloxacillin metabolism
Crustacea
Magnetic Resonance Spectroscopy
Models, Chemical
Spectrophotometry, Infrared
Anti-Bacterial Agents pharmacology
Anti-Infective Agents pharmacology
Biological Assay methods
Cloxacillin chemistry
Cobalt chemistry
Copper chemistry
Drug Evaluation, Preclinical
Microbial Sensitivity Tests
Nickel chemistry
Zinc chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1475-6366
- Volume :
- 21
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of enzyme inhibition and medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 17059178
- Full Text :
- https://doi.org/10.1080/14756360500397307