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Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats.
Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats.
- Source :
-
Psychopharmacology [Psychopharmacology (Berl)] 2006 Dec; Vol. 189 (2), pp. 175-86. Date of Electronic Publication: 2006 Oct 18. - Publication Year :
- 2006
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Abstract
- Rationale: The role of positive vs negative ethanol reinforcement in ethanol intake of Sardinian alcohol-preferring (sP) rats is unclear.<br />Objectives: To test the hypothesis that spontaneous ethanol self-administration of sP rats was sensitive to the opioid receptor antagonist naltrexone, whereas withdrawal-induced, but not spontaneous, ethanol self-administration would be sensitive to corticotropin-releasing factor(1) (CRF(1)) antagonists, implicating differential roles for positive and negative reinforcement, respectively.<br />Methods: Male sP rats operantly (FR1, 30 min/day) self-administered ethanol (10% v/v) until responding stabilized. One group (n=11) was made ethanol dependent through intermittent ethanol vapor exposure. Both nondependent (n = 10) and dependent rats received the CRF(1) antagonist LWH-63 (5, 10, and 20 mg/kg, s.c.). Separate nondependent sP rats (n = 10) received the opioid antagonist naltrexone (16, 50, 150, and 450 microg/kg, s.c.). Finally, CRF(1) antagonists (MJL-1-109-2, LWH-63, and R121919) were studied for their actions on home-cage ethanol drinking in nondependent sP rats (n = 6-8/group) under continuous, limited-access, or stressed conditions.<br />Results: Naltrexone potently reduced ethanol self-administration in nondependent sP rats. LWH-63 reduced heightened ethanol self-administration of vapor-sensitive, dependent sP rats. CRF(1) antagonists did not reduce ethanol intake in nondependent sP rats. R121919 (10 mg/kg, s.c.) retained antistress activity in sP rats, blunting novelty stress-induced suppression of ethanol intake.<br />Conclusions: Spontaneous ethanol self-administration of sP rats was opioid dependent with CRF(1) receptors implicated in withdrawal-induced drinking. Opioid and CRF(1) receptors play different roles in ethanol reinforcement and perhaps the ethanol addiction cycle. Such distinctions may apply to subtypes of alcoholic patients who differ in their motivation to drink and ultimately treatment response.
- Subjects :
- Alcohol Drinking drug therapy
Alcohol Drinking metabolism
Animals
Behavior, Addictive chemically induced
Behavior, Addictive metabolism
Behavior, Addictive psychology
Central Nervous System Agents pharmacology
Drinking drug effects
Ethanol administration & dosage
Ethanol pharmacology
Male
Naltrexone pharmacology
Pyrimidines pharmacology
Pyrroles pharmacology
Rats
Rats, Inbred Strains
Self Administration
Stress, Psychological drug therapy
Stress, Psychological metabolism
Stress, Psychological psychology
Triazines pharmacology
CRF Receptor, Type 1
Alcohol Drinking psychology
Narcotic Antagonists
Receptors, Corticotropin-Releasing Hormone antagonists & inhibitors
Reinforcement, Psychology
Subjects
Details
- Language :
- English
- ISSN :
- 0033-3158
- Volume :
- 189
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 17047935
- Full Text :
- https://doi.org/10.1007/s00213-006-0546-5