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Identification of pre- and postselection TCRalphabeta+ intraepithelial lymphocyte precursors in the thymus.
- Source :
-
Immunity [Immunity] 2006 Oct; Vol. 25 (4), pp. 631-41. - Publication Year :
- 2006
-
Abstract
- The immune system preserves and makes use of autoreactive lymphocytes with specialized functions. Here we showed that one of these populations, CD8alphaalpha(+)TCRalphabeta(+) intestinal intraepithelial lymphocytes (IELs), arose from a unique subset of double-positive thymocytes. This subset of cells was precommitted to preferentially give rise to CD8alphaalpha(+)TCRalphabeta(+) IELs, but they required exposure to self-agonist peptides. The agonist-selected TCRalphabeta(+) thymocytes are CD4 and CD8 double-negative, and their final maturation, including the induction of CD8alphaalpha expression, appeared to occur only after thymus export in the IL-15-rich environment of the gut. These developmental steps, including precommitment of immature thymocytes, TCR-mediated agonist selection, and postthymic differentiation promoted by cytokines, define a unique pathway for the generation of CD8alphaalpha(+)TCRalphabeta(+) IEL.
- Subjects :
- Animals
CD4 Antigens analysis
CD8 Antigens analysis
Cell Differentiation
Cytokines metabolism
Intestinal Mucosa cytology
Intestinal Mucosa immunology
Mice
Mice, Inbred Strains
Phenotype
T-Lymphocyte Subsets cytology
T-Lymphocyte Subsets drug effects
Thymus Gland cytology
Lymphocyte Activation
Receptors, Antigen, T-Cell, alpha-beta analysis
T-Lymphocyte Subsets immunology
Thymus Gland immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1074-7613
- Volume :
- 25
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Immunity
- Publication Type :
- Academic Journal
- Accession number :
- 17045820
- Full Text :
- https://doi.org/10.1016/j.immuni.2006.08.018