A framework for three-dimensional simulation of morphogenesis.

Authors :: Cickovski TM
Huang C
Chaturvedi R
Glimm T
Hentschel HG
Alber MS
Glazier JA
Newman SA
Izaguirre JA
Source :: IEEE/ACM transactions on computational biology and bioinformatics [IEEE/ACM Trans Comput Biol Bioinform] 2005 Oct-Dec; Vol. 2 (4), pp. 273-88.
Publication Year :: 2005
Abstract: We present COMPUCELL3D, a software framework for three-dimensional simulation of morphogenesis in different organisms. COMPUCELL3D employs biologically relevant models for cell clustering, growth, and interaction with chemical fields. COMPUCELL3D uses design patterns for speed, efficient memory management, extensibility, and flexibility to allow an almost unlimited variety of simulations. We have verified COMPUCELL3D by building a model of growth and skeletal pattern formation in the avian (chicken) limb bud. Binaries and source code are available, along with documentation and input files for sample simulations, at http:// compucell.sourceforge.net.

Subjects :: Animals
Cell Physiological Phenomena
Chick Embryo
Chickens
Chondrogenesis
Computing Methodologies
Database Management Systems
Energy Metabolism
Forelimb cytology
Forelimb embryology
Forelimb physiology
Programming Languages
User-Computer Interface
Computer Simulation
Models, Biological
Morphogenesis

Language :: English
ISSN :: 1545-5963
Volume :: 2
Issue :: 4
Database :: MEDLINE
Journal :: IEEE/ACM transactions on computational biology and bioinformatics
Publication Type :: Academic Journal
Accession number :: 17044166
Full Text :: https://doi.org/10.1109/TCBB.2005.46