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The impact of pregnancy and childbirth in the urethra of female rats.
- Source :
-
International urogynecology journal and pelvic floor dysfunction [Int Urogynecol J Pelvic Floor Dysfunct] 2007 Jun; Vol. 18 (6), pp. 645-51. Date of Electronic Publication: 2006 Oct 17. - Publication Year :
- 2007
-
Abstract
- The aim of this study was to evaluate the modifications in the amount of collagen, muscular, and elastic fibers in the mid-urethra of adult female rats during the pregnancy and after the natural childbirth, cesarean, and after simulated trauma of childbirth. The authors evaluated the histomorphometric aspects (collagen, muscular, and elastic fibers) in the mid-urethra of 70 animals distributed in seven groups: group 1 (n = 10)--control, group 2 (n = 10)--pregnant female rats, group 3 (n = 10)--female rats submitted to cesarean, group 4 (n = 10)--female rats with natural childbirth, group 5 (n = 10)--virgin female rats with simulated trauma of childbirth, group 6 (n = 10)--female rats submitted to cesarean followed by simulation of childbirth trauma, and group 7 (n = 10)--female rats with natural childbirth followed by simulation of childbirth trauma. The average concentration of collagen and elastic fibers and the collagen/muscular fiber correlation in groups 1, 2, and 3 were similar and significantly inferior to groups 4, 5, 6, and 7. The average of muscular fibers was similar in groups 1, 2, and 3 and significantly superior to groups 4, 5, 6, and 7. Pregnancy and cesarean did not induce alterations in collagen, muscular, and elastic fibers. However, the vaginal delivery and simulation of childbirth trauma determined the decrease in muscular fibers and the increase in collagen and elastic fibers and the correlation collagen/muscular fiber.
- Subjects :
- Animals
Collagen metabolism
Disease Models, Animal
Elastic Tissue anatomy & histology
Elastic Tissue pathology
Female
Muscles anatomy & histology
Muscles pathology
Postpartum Period physiology
Pregnancy
Pregnancy Complications pathology
Rats
Urethra pathology
Cesarean Section adverse effects
Natural Childbirth adverse effects
Urethra injuries
Subjects
Details
- Language :
- English
- Volume :
- 18
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- International urogynecology journal and pelvic floor dysfunction
- Publication Type :
- Academic Journal
- Accession number :
- 17043741
- Full Text :
- https://doi.org/10.1007/s00192-006-0221-8