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Uterine motility in the reptile Anolis carolinensis: interactive effects of tension, prostaglandins, calcium, and vasotocin.
- Source :
-
Journal of experimental zoology. Part A, Comparative experimental biology [J Exp Zool A Comp Exp Biol] 2006 Dec 01; Vol. 305 (12), pp. 1030-40. - Publication Year :
- 2006
-
Abstract
- Uteri of Anolis carolinensis exhibited spontaneous rhythmic contractions in vitro. Addition of arginine vasotocin (AVT) caused an immediate, strong, tonic contraction followed by rhythmic contractions with the same frequency as spontaneous contractions but of a greater amplitude. At low tension (1.5 g) the AVT-induced tonic contraction was blocked by low dose of indomethacin, suggesting that it is influenced by calcium rather than prostaglandins (PGs). An increase in tension (from 1.5 to 15 g) reduced the duration of the AVT-induced tonic contraction; this stretch-induced decrease was also blocked by indomethacin. Stretch also decreased the duration of the rhythmic contractions, but this stretch effect was not inhibited by indomethacin. The rest interval between rhythmic contractions was decreased by PGF2alpha and PGE2, and indomethacin or stretch blocked these PG effects. Indomethacin, AVT, or stretch alone did not affect PGF2alpha secretion from AVT-treated uteri. Stretch also reduced PGF2alpha secretion from AVT-treated uteri, an effect inhibited by indomethacin.<br /> (Copyright 2006 Wiley-Liss, Inc.)
Details
- Language :
- English
- ISSN :
- 1548-8969
- Volume :
- 305
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of experimental zoology. Part A, Comparative experimental biology
- Publication Type :
- Academic Journal
- Accession number :
- 17041917
- Full Text :
- https://doi.org/10.1002/jez.a.351